Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication
Identifieur interne : 001783 ( Main/Exploration ); précédent : 001782; suivant : 001784Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication
Auteurs : Albrecht Von Brunn [Allemagne] ; Sandra Ciesek [Allemagne] ; Brigitte Von Brunn [Allemagne] ; Javier Carbajo-Lozoya [Allemagne]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- déficit : Cyclophiline A.
- génétique : Cyclophiline A.
- métabolisme : Cyclophiline A.
- physiologie : Coronavirus humain 229E.
- Humains, Interactions hôte-pathogène, Polymorphisme de nucléotide simple, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Cyclophilin A.
- chemical , genetics : Cyclophilin A.
- chemical , metabolism : Cyclophilin A.
- physiology : Coronavirus 229E, Human.
- Host-Pathogen Interactions, Humans, Polymorphism, Single Nucleotide, Virus Replication.
Abstract
Non-immunosuppressive derivatives inhibit CoV replication Coronavirus NL63 and 229E replication depends on CypA. Coding non-synonymous SNP variants in the PPIA gene limit HCoV-229E replication.
Url:
DOI: 10.1016/j.coviro.2015.08.004
PubMed: 26318518
PubMed Central: 7102849
Affiliations:
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type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">German Center for Infection Research (DZIF), Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF)</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus 229E, Human (physiology)</term><term>Cyclophilin A (deficiency)</term><term>Cyclophilin A (genetics)</term><term>Cyclophilin A (metabolism)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus humain 229E (physiologie)</term><term>Cyclophiline A (déficit)</term><term>Cyclophiline A (génétique)</term><term>Cyclophiline A (métabolisme)</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Polymorphisme de nucléotide simple</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclophilin A</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclophiline A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus humain 229E</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus 229E, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Interactions hôte-pathogène</term><term>Polymorphisme de nucléotide simple</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Non-immunosuppressive derivatives inhibit CoV replication <italic>in vitro</italic>.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Coronavirus NL63 and 229E replication depends on CypA.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Coding non-synonymous SNP variants in the PPIA gene limit HCoV-229E replication.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. 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Chueh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, C" uniqKey="Luo C">C. Luo</name></author><author><name sortKey="Qu, H" uniqKey="Qu H">H. Qu</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X. Hu</name></author><author><name sortKey="Li, N" uniqKey="Li N">N. Li</name></author><author><name sortKey="Shu, D" uniqKey="Shu D">D. Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assimes, T L" uniqKey="Assimes T">T.L. Assimes</name></author><author><name sortKey="Holm, H" uniqKey="Holm H">H. Holm</name></author><author><name sortKey="Kathiresan, S" uniqKey="Kathiresan S">S. Kathiresan</name></author><author><name sortKey="Reilly, M P" uniqKey="Reilly M">M.P. Reilly</name></author><author><name sortKey="Thorleifsson, G" uniqKey="Thorleifsson G">G. Thorleifsson</name></author><author><name sortKey="Voight, B F" uniqKey="Voight B">B.F. Voight</name></author><author><name sortKey="Erdmann, J" uniqKey="Erdmann J">J. Erdmann</name></author><author><name sortKey="Willenborg, C" uniqKey="Willenborg C">C. Willenborg</name></author><author><name sortKey="Vaidya, D" uniqKey="Vaidya D">D. Vaidya</name></author><author><name sortKey="Xie, C" uniqKey="Xie C">C. Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gemmill, T R" uniqKey="Gemmill T">T.R. Gemmill</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Hanes, S D" uniqKey="Hanes S">S.D. Hanes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Hanovre</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Von Brunn, Albrecht" sort="Von Brunn, Albrecht" uniqKey="Von Brunn A" first="Albrecht" last="Von Brunn">Albrecht Von Brunn</name></region><name sortKey="Carbajo Lozoya, Javier" sort="Carbajo Lozoya, Javier" uniqKey="Carbajo Lozoya J" first="Javier" last="Carbajo-Lozoya">Javier Carbajo-Lozoya</name><name sortKey="Carbajo Lozoya, Javier" sort="Carbajo Lozoya, Javier" uniqKey="Carbajo Lozoya J" first="Javier" last="Carbajo-Lozoya">Javier Carbajo-Lozoya</name><name sortKey="Ciesek, Sandra" sort="Ciesek, Sandra" uniqKey="Ciesek S" first="Sandra" last="Ciesek">Sandra Ciesek</name><name sortKey="Ciesek, Sandra" sort="Ciesek, Sandra" uniqKey="Ciesek S" first="Sandra" last="Ciesek">Sandra Ciesek</name><name sortKey="Von Brunn, Albrecht" sort="Von Brunn, Albrecht" uniqKey="Von Brunn A" first="Albrecht" last="Von Brunn">Albrecht Von Brunn</name><name sortKey="Von Brunn, Brigitte" sort="Von Brunn, Brigitte" uniqKey="Von Brunn B" first="Brigitte" last="Von Brunn">Brigitte Von Brunn</name><name sortKey="Von Brunn, Brigitte" sort="Von Brunn, Brigitte" uniqKey="Von Brunn B" first="Brigitte" last="Von Brunn">Brigitte Von Brunn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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